We randomly assigned patients with atrial fibrillation and CHA2DS2-VASc score ≥2, to continued vs. We sought to understand the best strategy to manage the DOACs at the time of device surgery and specifically hypothesized that performing device surgery without DOAC interruption would result in a reduced haematoma rate. However, direct oral anticoagulants (DOACs) are now used to treat the majority of patients with atrial fibrillation.
#Bruise control 2 trial#
Guidelines recommend warfarin continuation rather than heparin bridging for pacemaker and defibrillator surgery, after the BRUISE CONTROL trial demonstrated an 80% reduction in device pocket haematoma with this approach.
13 McGill University Health Center, McGill University, and Hôpital Sacré-Coeur de Montréal, Montreal, QC, Canada. 12 QEII Health Sciences Centre, Dalhousie University, Halifax, NS, Canada. 
11 Service de Cardiologie, Hopital Henri Mondor, APHP, Creteil, France. 10 University of Alberta, 8440 112 St, Edmonton, AB, Canada. 9 Galilee Medical Center, 1 Ben Tzvi Blvd, Nahariya, Israel. 8 Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, 2725 chemin Ste-Foy, QC, Canada. 7 Southlake Regional Health Center, 581 Davis Dr, Newmarket, ON, Canada. 
6 Hôpital du Sacré-Coeur de Montréal, 5400 boul Gouin Ouest, Montreal, QC, Canada. 5 Libin Cardiovascular Institute, Foothills Medical Centre, University of Calgary, 1403 29th St. 4 Centre Hospitalier de L'Universite de Montreal, Hopital Hotel-Dieu, 850 St-Denis St., Montreal, QC, Canada. 3 Hopital Fleurimont, Universite de Sherbrooke, 3001 12e Ave Nord, Sherbrooke, QC, Canada. 2 Hamilton Health Sciences, Population Health Research Institute, McMaster University, 237 Barton St. 1 Department of Medicine, University of Ottawa, University of Ottawa Heart Institute, 40 Ruskin St., Ottawa, ON, Canada.
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